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Dr. Mohamed Mahmoud Ibrahim Al Sanea

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PERSONAL DATA:
Full Name: Mohamed Mahmoud Ibrahim Al Sanea
E-mail: mohmah80@gmail.com
Date of birth: October/28/1980


Education:
Ph.D. (2015),  Biological Chemistry,  Korea University of Science and Technology (UST); Chemical  Kinomics  Center,  Korea  Institute  of  Science  and Technology (KIST), Seoul, Republic of Korea.

M.Sc. (2006), Pharmaceutical Medicinal Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

B. Pharmaceutical Sciences (2002), Faculty of Pharmacy, Mansourah University, Mansourah, Egypt (with degree of honor). 


DISSERTATION:
PhD, Biological Chemistry; Targeting ROS1 Kinase with New Pyrazole, Isoxazole and Diarylurea Derivatives: Design, Synthesis and In vitro Anticancer Evaluation. 


FELLOWSHIPS AND AWARDS:
• UST award for overseas conference support, Korea University of Science and Technology, 2015. 

• Doctoral Scholarship, KIST IRDA-UST program, International Research and Development Academy, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea and Korea University of Science and Technology (UST), Daejeon, Korea. 2011. 

• Master Scholarship, Academy of Scientific Research and Technology, Cairo, Egypt, 2003. 


TEACHING EXPERIENCE:
• Lecturer, pharmacy department, International Academy for Health Sciences, Madina, Saudi Arabia (9/2007-2/2010).  

• Lecturer, pharmaceutical medicinal Chemistry department, Qassim University, Qassim, Saudi Arabia (2/2010-7/2011). 

• Lecturer, pharmaceutical medicinal Chemistry department, MTI University, Cairo, Egypt (10/2015-now). 


TEACHING INTERESTS:
• Teaching Drug design and virtual screening Software (MOE) during several workshops.
• Three practical courses of Medicinal Chemistry Curriculum for undergraduate PharmD students.
• Pharmaceutical Medicinal Chemistry courses for undergraduate Pharmacy students.


Research Papers:
• Ahmed Z. Abdelazem, Mohammad M. Al-Sanea, Hyun-Mee Park, So Ha Lee; Synthesis of new diarylamides with pyrimidinyl pyridine scaffold and evaluation of their anti-proliferative effect on cancer cell lines; Bioorganic and Medicinal Chemistry Letter. In Press, Corrected Proof, Available online 7 January 2016.

• Al-Sanea MM, Abdelazem AZ, Park BS, Yoo KH, Sim T, Kwon YJ, Lee SH;  ROS1 Kinase Inhibitors for Molecular-Targeted Therapies; Current Medicinal Chemistry. 2015 Oct 5. [Epub ahead of print]

• Ahmed Z. Abdelazem, Mohammad M. Al-Sanea, Hyun-Mee Park, So Ha Lee; Synthesis of new diarylamides with pyrimidinyl pyridine scaffold and evaluation of their anti-proliferative effect on cancer cell lines; Bioorganic & Medicinal Chemistry Letters, In Press, Accepted Manuscript, Available online 7 January 2016

• Ahmed Elkamhawy, Mohammad M. Al-Sanea, Chiman Song, Taebo Sim and Eun Joo Roh; Design and Synthesis of New [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Potential Antiproliferative Agents; Bull.Korean Chem. Soc. Wiley  2015, 36(7),1863–1873, 

• Mohammad   M.   Al-Sanea , Ahmed   Elkamhawy, Ahmed   Zakaria, Byung   Sun   Park, Youngjoo Kwon, So  Ha  Lee, Sang  Woo Lee and In Tae  Kim; Synthesis  and  in vitro  screening  of  phenyl bipyridinyl  pyrazole  derivatives  as  potential  antiproliferative  agents;  Molecules 2015, 20(1), 1031-1045. 

• Mohammad M. Al-Sanea, Byung Sun Park, Ahmed Z. Abdelazem, Khalid B. Selim, Kyung Ho Yoo, Taebo Sim, Jin Sung Tae, and So Ha Lee; Optimization of Bipyridinyl Pyrazole Scaffolds via Design, Synthesis and Screening of a New Series of ROS1 Kinase-modulating Compounds; Bull. Korean Chem. Soc. Wiley, 437, 2015. 

• Byung Sun Park*, Mohammad M. Al-Sanea*, (*co-first authors), Ahmed Z. Abdelazem, Hye Mi 
Park, Eun Joo Roh, Hyun-Mee Park, Kyung Ho Yoo, Taebo Sim, Jin Sung Tae, So Ha Lee. Structure- based optimization and biological evaluation of trisubstituted pyrazole as a core structure of potent ROS1 kinase inhibitors; Bioorganic and Medicinal Chemistry, 2014, 22, 3871–3878. 

• Ahmed Z. Abdelazem, Mohammad M. Al-Sanea, Byung Sun Park, Hye Mi Park, Kyung Ho Yoo, Taebo Sim, Jong Bae Park, Seung-Hoon Lee, So Ha Lee. Synthesis and biological evaluation of new   pyrazol-4-yl pyrimidine derivatives as potential inhibitors for selective ROS1 kinase. European Journal of Medicinal Chemistry, 2015, 90, 195-208. 

• B.S.  Park, A.Z.  Abdel-Azeem, M.M.  Al-Sanea, K.H.  Yoo, J.S.  Tae and S.H.  Lee  Staurosporine Analogues  from  Microbial  and  Synthetic  Sources  and  Their  Biological  Activities.  Current Medicinal Chemistry, 2013, 20, 3872-3902. 

• Mohammad M. Al-Sanea, Ibrahim M. El-deeb, So Ha Lee, Design, Synthesis and in-vitro Screening of New 1H-Pyrazole. Bull. Korean Chem. Soc. 2013, Vol. 34, No. 2 437 

• M.  M.   Al-Sanea,  A.  A.  Abdel-Hafez,  FA  Omar,  AF  Youssef,  Biotransformation  studies  of prednisone using human intestinal bacteria Part II: Anaerobic incubation and docking studies. 

• Journal of enzyme inhibition and medicinal chemistry. 24 (6), 1211-1219, 1, 2009. 

• Mohammed  M.  Al-Sanea,  Atef  A.  Abdel-Hafez,  Farghaly  A.  Omar  and  Adel  F.  Youssef; biotransformation studies of prednisone using human intestinal bacteria; part i: aerobic incubation; Bull. Pharm. Sci., Assiut University, 31, 2008. 215-228. 
 

CONFERENCES:
• Mohammad M. Al-Sanea,  So Ha Lee; Design, Synthesis and Biological Evaluation of New Diaryl Pyrazole Scaffold Based compounds with Potent ROS1 Kinase Modulating Activity, 5th International Conference on Chemistry and Chemical Process (ICCCP 2015), Amsterdam, Netherlands. February 2015. 

• Mohammad M. Al-Sanea, Ibrahim M. El-deeb, So Ha Lee; Design, synthesis and in-vitro screening of potential ROS1 kinase inhibitors having 4-(2-phenyl)pyridin-4-yl 1H-pyrazole scaffold and its isoxazole analogues. 113th Meeting of Korean Chemical Society, Seoul, Korea. April 2014. 

• Mohammad M.  Al-Sanea,  Byung  Sun  Park,  Jin  Sung  Taeb,  So  Ha  Lee,  Optimization  of Bipyridinyl Pyrazole Scaffold via Design, Synthesis and Screening  a New Series of ROS1 Kinase Modulating Compounds, 114th Meeting of Korean Chemical Society, Gwangjo, Korea. Oct 2014 

• Mohammad M. Al-Sanea, Ahmed Z. Abdelazem and So Ha Lee, Pyrazole derivatives as potential antineoplastic agents, Korean oil chemist’s annual meeting, Seoul, Korea. November 2014. 

• Mohammed M.  Al-Sanea, Atef A.  Abdel-Hafez, Farghaly A.  Omar and Adel F.  Youssef, biotransformation studies of prednisone using human intestinal bacteria; part i: Aerobic incubation A poster in the Assiut University 5th Pharmaceutical Science Conference, Faculty of Pharmacy, Assiut, Egypt. March 2006. 
 

Patents:
• LEE, So Ha; YOO, Kyung Ho; SIM, Tae Bo; Ahmed Zakaria Abdelazem; PARK, Hye Mi; Mohammad Mahmoud Alsanea; PARK, Byung Sun; 2,4,6-Trisubstituted pyrimidine compounds for ROS kinase inhibitors. Korean Patent 10-2013-0129611. 


ACADEMIC LECTURES:
Plentiful academic lectures for undergraduate Pharmacy students.


ACADEMIC WORKSHOPS:
• Chemical and Biorisk Management Workshop; 26-28 Jan, 2016, Cairo, Egypt.

• Molecular Operating Environment (MOE) software for Drug Design Workshop; March, 2007, Assiut, Egypt

ACADEMIC AND PROFESSIONAL ORGANIZATIONS:
• Member of the Korean Chemical Society, 2013. 
• Member of Egyptian Pharmaceutical Syndicate, 2002. 


REFERENCES:
• Dr. So Ha Lee 
Chemical Kinomics Research Center 
Korea Institute of Science and Technology (KIST) 
39-1, Hawolgok-dong, Seongbuk-gu, Seoul, S. Korea <136-791> 
Tel. Lab +82-2-958-6795, office +82-2-958-6834, H.P 010-4172-8843, 
Fax. +82-2-958-5189 E-mail:  lsh6211@kist.re.kr
 
• Prof. Dr. Adel Fawzy Youssef 
E. Professor of Pharm. Med. Chemistry, Pharm. Med. Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Tel. 002-088-2411298 , Fax. 002-088-2332776 
E-mail: adelfawzyyoussef@yahoo.com, adel.mohyeldeen@pharm.au.edu.eg 
 
• Dr. Yoo Kyung Ho 
Chemical Kinomics Research Center 
Korea Institute of Science and Technology (KIST) 
39-1, Hawolgok-dong, Seongbuk-gu, Seoul, Korea <136-791> 
Tel. +82-2-958-5152  
E-mail : khyoo@kist.re.kr

• Prof. Nadia Mohamed Ahmed Mahfouz
Department of Medicinal Chemistry, 
Faculty of Pharmacy, Assiut University, Assiut, Egypt
Office Tel. +2-088-232-7315; Mobile No.: 01065745002; 
Fax No.: +20882080774
E-Mail: nadia_mahfouz@yahoo.com, nadia.mahfouz@pharm.au.edu.eg 

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